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The Covid-19 pandemic brought many businesses to a standstill as international travel restriction was imposed across countries in addition to a national lockdown. Firm performances were depressed due to reduced order and output. This study examines whether digitalization has mitigated the negative impact of the Covid-19 pandemic on Malaysia's manufacturing sector. Using sales as the performance yardstick of 24 industrial sectors from January to December 2020, our result shows that manufacturing sales performance was negatively related to the Covid-19 pandemic. However, the adverse impact of Covid-19 was mitigated with a higher level of digitalization. The mitigating role of digitalization remains robust in further analysis. This study has managed to quantify the mitigating effect of Covid-19 on manufacturing sectors. As a policy implication, the government should expedite the introduction of the 5G network, promote digital adoption across all sectors to ensure business continuity and provide an effective response mechanism in any pandemic or crisis. © 2023, University of Wollongong. All rights reserved.
ABSTRACT
Voriconazole is a fluoride-containing anti-fungal. Prolonged exposure can result in fluoride deposition within the bone extracellular matrix, resulting in periostitis and arthritis. We report a patient who developed widespread bony pain and polyarthralgia while on voriconazole therapy for COVID-19-associated pulmonary aspergillosis. No associated autoimmune rheumatic disease or alternative cause was noted. Blood investigations showed elevated total serum alkaline phosphatase, bone-specific ALP and fluoride levels, with normal serum voriconazole levels. A whole body nuclear bone scan showed multifocal periostitis. A diagnosis of voriconazole-induced periostitis and arthritis was made. Complete resolution of clinical symptoms with normalisation of the serum ALP occurred within four weeks of voriconazole cessation. While voriconazole-induced periostitis/arthritis is a recognised phenomenon in solid organ and haematopoietic stem cell transplant patients on long-term voriconazole, this case highlights the importance of having a high index of suspicion in other settings including CAPA. Clinical presentation can be mistaken for bony metastatic disease or other inflammatory arthritis.
ABSTRACT
The Covid-19 pandemic brought many businesses to a standstill as international travel restriction was imposed across countries in addition to a national lockdown. Firm performances were depressed due to reduced order and output. This study examines whether digitalization has mitigated the negative impact of the Covid-19 pandemic on Malaysia's manufacturing sector. Using sales as the performance yardstick of 24 industrial sectors from January to December 2020, our result shows that manufacturing sales performance was negatively related to the Covid-19 pandemic. However, the adverse impact of Covid-19 was mitigated with a higher level of digitalization. The mitigating role of digitalization remains robust in further analysis. This study has managed to quantify the mitigating effect of Covid-19 on manufacturing sectors. As a policy implication, the government should expedite the introduction of the 5G network, promote digital adoption across all sectors to ensure business continuity and provide an effective response mechanism in any pandemic or crisis.
ABSTRACT
Purpose of Study: Between September 2020 and November 2021, a survey was developed in partnership with children, youth, and community members experiencing vulnerabilities in a Vancouver Inner City Neighbourhood (ICN) to explore challenges encountered during the COVID-19 pandemic. In the survey, participants were asked questions about their financial status, housing security, food accessibility, and other social determinants of health. Other equity-seeking groups in Vancouver, including youth experiencing developmental and/or other medical diversity, wished to adapt the ICN COVID-19 survey to explore the impact of the pandemic in their community. These youth are active members of the province's pediatric tertiary care teaching hospital's Youth Advisory Committee (YAC), and in sharing their lived experience as patients, they strive to improve the quality of healthcare for children and youth throughout British Columbia. The objectives of this study were to: 1) adapt the COVID-19 survey to capture the views and needs of youth experiencing developmental and/or other medical diversity;and 2) identify how the COVID-19 pandemic impacted this group's social determinants of health. Methods Used: Ethics board approval was obtained for this observational, cross-sectional study (H20-00987). The research team and YAC co-constructed an adapted COVID-19 survey via Zoom dialogues. YAC members completed the survey online via Qualtrics from May 2022-August 2022. Demographic information and survey results were analyzed using descriptive statistics. Summary of Results: In total, 12 participants completed the survey, including 11 youth and 1 staff member. The median age of the youth participants was 23 years (n=11, min=14, max=29). During the COVID-19 pandemic, 82% (9/11) of youth reported changes in their ability to attend work or school, 36% (4/11) reported concern around reliable and affordable access to medications/medical treatment, and 46% (5/11) reported difficulty in caring for themselves. 46% (5/11) of youth also reported difficulty in caring for older adults or people in their families with disabilities. Many youth (6/11;55%) reported they had less than five people to turn to for support in times of stress, and 46% (5/11) of youth reported the pandemic changed their ability to connect with these people. Furthermore, 82% (9/11) of youth reported experiencing some level of distress related to the pandemic. 73% (8/11) of youth reported heightened anxiety, 82% (9/11) reported worsened mood, 55% (6/11) reported difficulty sleeping, and 64% (7/11) reported difficulty exercising. Conclusion(s): Youth with developmental and/or other complex medical diversity experienced difficulties accessing work and education, reliable and affordable medical care, and social support due to the COVID-19 pandemic. The pandemic negatively impacted the social, emotional, and physical wellbeing of these youth, indicating a need for future dialogue and advocacy to ensure the views and voices on rights of children and youth are honoured.
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BACKGROUND: Public health mandates associated with COVID-19 added unprecedented stress on families, providers and the health care systems;including our ambulatory multidisciplinary cleft team care. In order to continue to provide responsive, multidisciplinary team (MDT) cleft and craniofacial care, it was essential to identify direct and indirect impacts of COVID-19 on our patients and families, whilst planning ahead for ongoing coordinated surgical, pediatric, and psychosocial interventions. Our team developed a short on-line psychosocial screening questionnaire that was administered prior to our MDT clinics, using a What Matters to You quality improvement (QI) format. OBJECTIVE(S): 1.To establish and test the utility of a What Matters to You quality improvement (QI) questionnaire. 2.To use this questionnaire in order to understand the impact of the COVID-19 pandemic on patients and family access to health services. DESIGN/METHODS: Our team developed a 5-question online smartphone- accessible survey and distributed this to families prior to their MDT clinic visit during the COVID-19 pandemic. We analyzed survey results from May 2020-October 2021 in order to understand the impact of COVID-19 on families as well as the utility of our survey system. RESULT(S): Out of 110 sequential MDT visits, families reported that COVID impacted timely access to health services (20%);employment (32%);basic needs like food and shelter (13%);and social capital. Almost half (47%) reported less than 5 people to turn to for extra support. The most common concerns caregivers have about their children were development, learning, and/or school progress (38%);mental health (36%) and social emotional well-being (31%). CONCLUSION(S): Our study shows that 5 key psychosocial screening questions can be utilized to facilitate care coordination, responsiveness, and triage for in-person and virtual care settings, and respond to family centred care priorities in the midst of evolving COVID-19 landscapes.
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Background: TLR7/8 are immune receptors expressed in megakaryocytes which detects single-stranded RNA viruses such as SARS-CoV- 2. There is increasing evidence that in addition to raised platelet counts, severe infection with SARS-CoV- 2 increases the risk of venous, arterial and microvascular coagulation. Aim(s): To determine if ssRNA viruses are capable of increasing thrombopoeisis through direct interaction with megakaryocytes. Method(s): Cells were incubated with and without Gardiquimod (GDQ), a specific agonist of TLR7/8 in cord blood derived (CBMKs) and mouse bone marrow derived megakaryocytes (mMKs). TLR7/8-/- iPSC derived megakaryocytes (iPSC-MKs) were produced using CRISPR Cas9 editing of iPSCs and forward programming using an doxycyclin inducible cassette. GFP labelled SARS-CoV- 2 virus was incubated with the TLR7/8-/- iPSC- MKs and wild-type iPSC-MKs. Result(s): Incubation with GDQ increased platelet production in CBMKs and mMKs, and increased platelet function. Increased platelet counts were seen in mice treated with GDQ, and mice infected with influenza. Incubation with GDQ induced increased expression of IL1beta in the parental iPSC-MKs, however in the TLR7-/- and TLR7/8-/- MKs, no increased expression was observed. There was a significant increase in platelet production from the parental iPSC-MKs in response to incubation with GDQ, which was not seen in the TLR7-/- and TLR7/8-/- MKs. Incubation of the GFP-labelled SARS-CoV- 2 virus with wild-type MKs did not lead to a significant increase in fluorescence. Only very low level viral sequences were found in the cells post-incubation demonstrating that penetration within the MKs is unlikely to be of significance. Studies are ongoing to ascertain whether SARS-CoV- 2 induces outside in signalling leading to changes in transcription within the MKs (such as elevation of IL1beta). Conclusion(s): TLR7/8 agonists, including ssRNA genome viruses, increase platelet production and functionality from megakaryocytes. SARS-CoV- 2 does not appear to penetrate and significantly replicate within MKs, however incubation with megakaryocytes did show elevated expression of IL1beta. (Figure Presented).
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With the rapid development of internet finance in China, the risk management of internet finance has become an urgent issue. This study analyzes the factors that affect the default risk of Chinese internet finance companies based on measuring the distance to default of companies. This study incorporates ESG rating into the evaluation model to comprehensively reflect the default risk factors. The traditional KMV model is modified with ESG rating, and results are used to construct the panel logit model. Based on internet finance firms listed on China A-Shares data from 2016 to 2020, our results show the following: first, the modified ESG-KMV logit model can effectively analyze the influencing factors of the internet finance default risk. Second, ROE, accounts receivable turnover ratio, asset-liability ratio and z-value are important factors that affect the default risk of internet finance companies. Third, it is also found that COVID-19 has significantly impacted the default risk of internet finance companies. As a policy implication, the regulator can incorporate ESG into the measurement of the default risk to create more awareness among internet finance companies on the importance of the environment and sustainability to human societies. Copyright © 2022 Zeng, Lau and Abdul Bahri.
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The purposes of this paper are (i) to examine 3 driving factors affecting China A-shares market performance;namely systematic risk, idiosyncratic risk, and market sentiment, and (ii) to investigate the relationship between state-owned enterprise (SOE) & non-SOE and stock returns. In addition, the study also analyze normal condition and the impacts of Sino-US trade war and Covid-19 pandemic. This study employs monthly data which is divided into two parts namely (i) 2004-2020 period and (ii) 2018-2020 period. Multiple classic asset pricing models are employed to investigate the impacts of the 3 driving factors on stock returns. The results showed that these 3 driving factors exert significant influence on China A-shares in 2004-2020, However, the impact of market sentiment is weak during the period 2018-2020. Furthermore, market risks, firm size and B/M factor show great impacts on both SOE and non-SOE, profitability factor affecting non-SOE stock return is more important than investment which improves SOE stock return. This study proposes that investors and companies pay more attention to systematic risk and idiosyncratic risk, which potentially have greater impact on the stock market and to reduce unnecessary economic losses © International Journal of Economics and Management
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Decentralised clinical trials offer great potential to improve the clinical trial paradigm, bringing more diversity and less burden to the participants we serve. Adoption of decentralised clinical trials by industry had been slow until the COVID-19 pandemic triggered a need to adapt to new ways of keeping clinical research moving forward. Several consortiums have helped to define the opportunity of decentralised clinical trials and regulators, responding to the global pandemic, and have provided opportunities to implement approaches that were not formally available previously. Nevertheless, barriers to implementation persist, including a lack of clear regulatory expectations and insufficient organisational readiness. Additional efforts are required to support the cultural shift needed to embed these services as a standard option across clinical trials.
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Background/Purpose: The public health mandates associated with COVID-19 to decrease transmission in children and youth added unprecedented stress on families, providers and health care systems, including ambulatory multidisciplinary cleft/craniofacial team care. In order to provide responsive, multidisciplinary team (MDT) cleft and craniofacial care, it was essential to identify direct and indirect impacts of COVID-19 on our patients and families, whilst planning ahead for ongoing coordinated surgical, pediatric, and psychosocial interventions. The purpose of this Platform presentation is to discuss how incorporating a short on-line psychosocial screening questionnaire prior to a MDT clinic, using a 'What Matters to You' quality improvement (QI) format, can facilitate care coordination and responsiveness, triage for in-person and virtual care settings, and respond to family centred care priorities in the midst of evolving COVID-19 landscapes. Methods/Description: Description - During this platform paper, the interdisciplinary team coordinator and/or pediatrician from a large North American multidisciplinary Cleft Craniofacial Program will present the key findings from a quality improvement project conducted during the concurrent COVID-19 pandemic. The use of a smart phone accessible data system to record QI data will also be discussed. Main Objectives of Presentation - At the end of this presentation, the learner will list 5 key psychosocial screening questions to triage patients in need of addition supports exacerbated by the COVID-19 pandemic. Care coordinators will discuss key findings and the application of similar approaches in other team settings to address direct and indirect care needs exacerbated by COVID-19 and its aftermath. Key Findings and Insights - Out of 110 sequential MDT visits, families reported that COVID impacted timely access to health services (20%);employment (32%);basic needs like food and shelter (13%);and social capital. Almost half (47%) reported less than 5 people to turn to for extra support. The most common concerns caregivers reported about their children were development, learning, and/or school progress (38%);mental health (36%) and social emotional well-being (31%).